For immunochemical detection of ApoA1
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ApoA1 Polyclonal Antibody

Item No. 10008463

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Apolipoprotein A1
Immunogen
Synthetic peptide from an internal region of human ApoA1
Formulation (Request formulation change)
500 μl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IF, IHC, and WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
P02647
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 μl)

    $347

    Add
    Cayman Chemical
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    Product Description

    ApoA1 is a major protein component in high-density lipoproteins (HDLs). It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues as well as transporting cholesterol to the liver and other tissues for excretion and steroidogenesis.1 Serum ApoA1 levels are inversely related to the risk of developing atherosclerosis.2 Loss-of-function mutations in ApoA1 are causes of diseases such as HDL deficiency type 1 (or Tangier disease) and type 2 (familial hypoalphalipoproteinemia), and systemic non-neuropathic amyloidosis.3,4 Liver and small intestine are two main sources of the protein. Cayman’s ApoA1 Polyclonal Antibody detects the protein by WB analysis at 25 kDa in tissue/cell samples such as liver, intestine, and HepG2 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., et al. Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases. Proc. Natl. Acad. Sci. USA 103(7), 2126-2131 (2006).

    2. Haas, M.J., Reinacher, D., Li, J.P., et al. Regulation of apoA1 gene expression with acidosis: Requirement for a transcriptional repressor. J. Mol. Endocrinol. 27(1), 43-57 (2001).

    3. Tall, A.R., and Wang, N. Tangier disease as a test of the reverse cholesterol transport hypothesis. J. Clin. Invest. 106(10), 1205-1207 (2000).

    4. Cheung, M.C., Mendez, A.J., Wolf, A.C., et al. Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling tangier disease and their effects on intracellular cholesterol efflux. J. Clin. Invest. 91(2), 522-529 (1993).