A form of vitamin E with diverse biological activities
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δ-Tocotrienol

Item No. 10008513

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-2,8-dimethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol
CAS Number
25612-59-3
Molecular Formula
C27H40O2
Formula Weight
396.6
Purity
≥98%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
298 nm
SMILES
C/C(CC/C=C(C)/CC/C=C(C)/C)=C\CC[C@@]1(C)OC2=C(C)C=C(O)C=C2CC1
InChi Code
InChI=1S/C27H40O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h10,12,14,18-19,28H,7-9,11,13,15-17H2,1-6H3/b21-12+,22-14+/t27-/m1/s1
InChi Key
ODADKLYLWWCHNB-LDYBVBFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.1,2,3,4 It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.2 δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.3 It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).5 [Matreya, LLC. Catalog No. 2112]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kamal-Eldin, A., and Appelqvist, L.-Å. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31(7), 671-701 (1996).

    2. Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47(6), 904-915 (2004).

    3. Naito, Y., Shimozawa, M., Kuroda, M., et al. Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expresion of adhesion molecules. Atherosclerosis 180, 19-25 (2005).

    4. Shen, J., Yang, T., Xu, Y., et al. δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages. Int. J. Mol. Sci. 19(10), 3022 (2018).

    5. Damiano, S., Navas, L., Lomabari, P., et al. Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats. J. Cell. Physiol. 233(11), 7831-8739 (2018).