A selective agonist of GPR119
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PSN375963

Item No. 10008593

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine
CAS Number
388575-52-8
Molecular Formula
C17H23N3O
Formula Weight
285.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 5 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.25 mg/ml
λmax
224, 273 nm
SMILES
CCCCC1CCC(CC1)c1onc(n1)c1ccncc1
InChi Code
InChI=1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3
InChi Key
OAVLEYPTWABFLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $20

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    5 mg

    $81

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    10 mg

    $142

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    25 mg

    $306

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    PSN375963 is a potent and selective agonist of GPR119 that shows similar potency to oleoyl ethanolamide (OEA) at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 8.4 and 7.9 µM, respectively (EC50 values for OEA are 3.2 and 2.9 µM, respectively).1 These data suggest that PSN375963 may be useful as a therapeutic agent for the treatment of obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Overton, H.A., Babbs, A.J., Doel, S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3(3), 167-175 (2006).