An NMDA receptor antagonist
Related Products
Isomer(s)
27213(−)-MK-801 (maleate)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(+)-MK-801 (hydrogen maleate)

Item No. 10009019

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-5S-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate
CAS Number
77086-22-7
Synonyms
  • Dizocilpine
Molecular Formula
C16H15N • C4H4O4
Formula Weight
337.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:9): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/ml
SMILES
C[C@@]12C3=CC=CC=C3[C@@](N2)([H])CC4=CC=CC=C41.O=C(/C=C\C(O)=O)O
InChi Code
InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
InChi Key
QLTXKCWMEZIHBJ-PJGJYSAQSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $80

    Add

    50 mg

    $293

    Add
    Product Description

    MK-801 is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) (Item No. 14581) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux.1 It has been shown to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, E.H.K., Kemp, J.A., Priestley, T., et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc. Natl. Acad. Sci. USA 83(18), 7104-7108 (1986).

    2. Hatfield, R.H., Gill, R., and Brazell, C. The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur. J. Pharmacol. 216(1), 1-7 (1992).

    3. Scheggi, S., Mangiavacchi, S., Masi, F., et al. Dizocilpine infusion has a different effect in the development of morphine and cocaine sensitization: Behavioral and neurochemical aspects. Neuroscience 109(2), 267-274 (2002).