An excitatory neurotransmitter
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NMDA

Item No. 14581

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-D-aspartic acid
CAS Number
6384-92-5
Synonyms
  • N-Methyl-D-Aspartic Acid
Molecular Formula
C5H9NO4
Formula Weight
147.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC([C@H](NC)CC(O)=O)=O
InChi Code
InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChi Key
HOKKHZGPKSLGJE-GSVOUGTGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $68

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    100 mg

    $112

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    250 mg

    $258

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    500 mg

    $355

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    Product Description

    NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate.1,2 Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity.3 Repetitive activation of NMDA synapses leads to long-term potentiation, which is used as a model of learning and the initial stages of memory formation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishii, T., Moriyoshi, K., Sugihara, H., et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. The Journal of Biological Chemisty 268(4), 2836-2843 (1993).

    2. Ferkany, J.W., Zaczek, R., and Coyle, J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298(19), 757-759 (1982).

    3. Nakanishi, S. Molecular diversity of glutamate receptors and implications for brain function. Science 258(5082), 597-603 (1992).

    4. Izquierdo, I. Role of NMDA receptors in memory. Trends Pharmacol. Sci. 12(4), 128-129 (1991).