Inhibitor of PI3Kγ
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CAY10505

Item No. 10009078

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CAS Number
328960-84-5
Molecular Formula
C14H8FNO3S
Formula Weight
289.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
λmax
238, 270, 389 nm
SMILES
Fc1ccc(cc1)c1ccc(/C=C2\SC(=O)NC/2=O)o1
InChi Code
InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
InChi Key
UFBTYTGRUBUUIL-KPKJPENVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    25 mg

    $178

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    50 mg

    $312

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    Product Description

    CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1 Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1 Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J. Med. Chem. 49(13), 3857-3871 (2006).

    Product Citations

    Sun, Y.-Y., Lin, S.-H., Lin, H.-C., et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS One 8(7), e69019 (2013).