An inactive enantiomer of W146
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Enantiomer(s)
10009109W146 (trifluoroacetate salt)
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W140 (trifluoroacetate salt)

Item No. 10009110

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3S-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate)
CAS Number
909725-64-0
Molecular Formula
C16H27N2O4P • CF3COOH
Formula Weight
456.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 0.15 mg/ml
λmax
207, 246 nm
SMILES
CCCCCCC1=CC=CC(NC([C@@H](N)CCP(O)(O)=O)=O)=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C16H27N2O4P.C2HF3O2/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;3-2(4,5)1(6)7/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);(H,6,7)/t15-;/m0./s1
InChi Key
JDWCNCPWPLHFEX-RSAXXLAASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $86

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    W140 is the inactive enantiomer of the sphingosine-1-phosphate receptor 1 (S1P1) antagonist W146 (Item No. 10009109).1 It only weakly binds to S1P1 (Ki = 4.6 µM for the human receptor). W140 has been used as a negative control in vitro and in vivo in the study of S1P1 signaling.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sanna, M.G., Wang, S.K., Gonzalez-Cabrera, P.J., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat. Chem. Biol. 2(8), 434-441 (2006).

    2. Li, C., Chi, X.X., Xie, W., et al. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. J. Neurophysiol. 108(5), 1473-1483 (2012).