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Bezafibrate

Item № 10009145
CAS № 41859-67-0
Purity ≥98%
product image
                (CAS 41859-67-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 mg $9.00 0.00
     1 g $17.00 0.00
     5 g $72.00 0.00
     10 g $126.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • Benzofibrate
  • Bezalip
  • Bezatrol
  • BM 15075
  • Difaterol

Bezafibrate is a well established pan-peroxisome proliferator-activated receptor (pan-PPAR) activator. This fibrate drug has over 25 years of therapeutic use with a good safety profile. The fibrate class of drugs are generally known as PPARα agonists, but bezafibrate appears to activate PPARδ and PPARγ as well. Bezafibrate activates human PPARα, PPARδ, and PPARγ with EC50 values of 50, 20, and 60 µM, respectively, in a cell-based transcription assay.1 Bezafibrate is used to treat hyperlipidemia. It helps lower low-density lipoprotein cholesterol and triglycerides while raising high-density lipoprotein cholesterol levels. It also improves insulin sensitivity and reduces blood glucose levels, which in combination with the cholesterol effects significantly lowers the incidence of cardiovascular events and development of diabetes in patients with features of metabolic syndrome.2

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Technical Information
Formal Name
2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid
CAS Number
41859-67-0
Synonyms
  • Benzofibrate
  • Bezalip
  • Bezatrol
  • BM 15075
  • Difaterol
Molecular Formula
C19H20ClNO4
Formula Weight
361.8
Purity
≥98%
Formulation
A crystalline solid
λmax
229 nm
SMILES
ClC1=CC=C(C(NCCC2=CC=C(OC(C)(C)C(O)=O)C=C2)=O)C=C1
InChI Code
InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
InChI Key
IIBYAHWJQTYFKB-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery J. Med. Chem. 43(4), 528-550 (2000).

2. Tenenbaum, A., Motro, M., and Fisman, E.Z. Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons Cardiovascular Diabetology 4(14), 1-5 (2005).

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