A potent EP4 receptor antagonist
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GW 627368X

Item No. 10009162

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide
CAS Number
439288-66-1
Molecular Formula
C30H28N2O6S
Formula Weight
544.6
Purity
≥96%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 10 mg/ml
λmax
217, 229, 248, 295, 353 nm
SMILES
CCOc1c2C(=O)N(Cc2c(OCC)c2ccccc12)c1ccc(cc1)CC(=O)NS(=O)(=O)c1ccccc1
InChi Code
InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
InChi Key
XREWXJVMYAXCJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $279

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    10 mg

    $493

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    25 mg

    $1,077

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    Product Description

    GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively.1 Affinity for all other human prostanoid receptors is >5.0 µM. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wilson, R.J., Giblin, G.M.P., Roomans, S., et al. GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): A novel, potent and selective prostanoid EP4 receptor antagonist. Br. J. Pharmacol. 148, 326-339 (2006).