For immunochemical detection of PSD-95
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Product Categories

Product Type

Antibodies
Primary Antibodies
Polyclonal Antibodies

Research Area

Neuroscience

Application

Western Blot

PSD95 Polyclonal Antibody

Item No. 10009506

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Postsynaptic Density Protein of 95
Immunogen
peptide corresponding to amino acid residues from the N-terminal region of rat PSD95
Formulation (Request formulation change)
Affinity-purified IgG
Host
Rabbit
Applications
WB
Species Reactivity
(+) Rat(+) Mouse(+) Bovine PSD-2 (expected)(+) Human PSD-2 (expected)(+) Non-Human primates PSD-2 (expected)(+) Zebrafish PSD-2 (expected)
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 ea

    $464

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    Product Description

    PSD95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses.1 Recent work suggests that interaction of the NMDAR with PSD95 via these PDZ domains can be regulated by phosphorylation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ye, B., Liao, D., Zhang, X., et al. GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26, 603-617 (2000).

    2. Scannevin, R.H., and Huganir, R.L. Postsynaptic organization and regulation of excitatory synapses. Nat. Rev. Neurosci. 1(2), 133-141 (2000).