A synthetic compound that promotes self-renewal of murine embryonic stem cells
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SC-1

Item No. 10009557

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
CAS Number
839707-37-8
Synonyms
  • Pluripotin
Molecular Formula
C27H25F3N8O2
Formula Weight
550.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlDMSO:PBS (7.2 pH) 1:2: 0.3 mg/ml
SMILES
Cc1nn(C)c(Nc2ncc3CN(c4cc(ccc4C)NC(=O)c4cccc(c4)C(F)(F)F)C(=O)N(C)c3n2)c1
InChi Code
InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
InChi Key
NBZFRTJWEIHFPF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.1 The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.1 Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, S., Do, J.T., Zhang, Q., et al. Self-renewal of embryonic stem cells by a small molecule. Proc. Natl. Acad. Sci. USA 103(46), 17266-17271 (2006).