A LTB4 receptor antagonist
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LY293111

Item No. 10009768

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]4-yl)oxy]propoxy]-2-propylphenoxy]-benzoic acid
CAS Number
161172-51-6
Synonyms
  • Etalocib
  • VML 295
Molecular Formula
C33H33FO6
Formula Weight
544.6
Purity
≥98%
Formulation (Request formulation change)
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
205, 256, 294 nm
SMILES
CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(F)cc2)cccc1Oc1ccccc1C(=O)O
InChi Code
InChI=1S/C33H33FO6/c1-3-9-25-29(12-7-13-30(25)40-31-11-6-5-10-26(31)33(36)37)38-18-8-19-39-32-21-28(35)27(20-22(32)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)
InChi Key
YFIZRWPXUYFCSN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $72

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    1 mg

    $137

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    5 mg

    $358

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    10 mg

    $501

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    Product Description

    LY293111 is a potent antagonist of the leukotriene B4 (LTB4) receptor, BLT1, that inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 17.6 nM and inhibits the LTB4-induced chemotaxis of human neutrophils with an IC50 value of 6.3 nM.1 LY293111 inhibits growth of MiaPaCa-2 and AsPC-1 human pancreatic cancer cells in vitro (250-1,000 nM) and subcutaneous xenografts in athymic mice (250 mg/kg/day), inducing apoptosis and S-phase arrest.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jackson, W.T., Froelich, L.L., Boyd, R.J., et al. Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: In vitro studies. J. Pharmacol. Exp. Ther. 288(1), 286-294 (1999).

    2. Tong, W.G., Ding, X.Z., Hennig, R., et al. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Clin. Cancer Res. 8, 3232-3242 (2002).

    Product Citations

    Mihlan, M., Wissmann, S., Gavrilov, A., et al. Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay. Cell S0092-8674(24), 00774-00778 (2024).