A LTB4 receptor antagonist
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LY223982

Item No. 10010024

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexenyl]oxy]-benzenepropanoic acid
CAS Number
117423-74-2
Synonyms
  • CGS 23131
  • SKF 107324
Molecular Formula
C30H30O7
Formula Weight
502.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: .1 mg/ml
λmax
203, 260, 296 nm
SMILES
COc1ccc(/C=C\CCCCOc2ccc(cc2CCC(=O)O)C(=O)c2cccc(c2)C(=O)O)cc1
InChi Code
InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
InChi Key
SYZSSLLFRVDRHL-QPJJXVBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    10 mg

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    25 mg

    $493

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    Product Description

    The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM.1 LY223982 inhibits the LTB4-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively.2 However, concentrations of LY223982 up to 10 µM do not inhibit binding of LTB4 to human BLT1 or BLT2 expressed in CHO cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gapinski, D.M., Mallett, B.E., Froelich, L.L., et al. Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain. J. Med. Chem. 33(10), 2807-2813 (1990).

    2. Jackson, W.T., Boyd, R.J., Froelich, L.L., et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J. Pharmacol. Exp. Ther. 263(3), 1009-1014 (1992).

    3. Yokomizo, T., Kato, K., Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. The Journal of Biological Chemisty 276(15), 12454-12459 (2001).