A FAAH inhibitor
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CAY10570

Item No. 10010032

Technical Information
Formal Name
3-decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone
CAS Number
875014-22-5
Molecular Formula
C25H32N2OS
Formula Weight
Purity
≥98%
Formulation
A 1 mg/ml solution in methyl acetate
DMF: 20 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
203, 273 nm
SMILES
CCCCCCCCCCN1C(=S)NC(c2ccccc2)(c2ccccc2)C1=O
InChi Code
InChI=1S/C25H32N2OS/c1-2-3-4-5-6-7-8-15-20-27-23(28)25(26-24(27)29,21-16-11-9-12-17-21)22-18-13-10-14-19-22/h9-14,16-19H,2-8,15,20H2,1H3,(H,26,29)
InChi Key
ACGQTBAFQLDLFS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    The enzyme fatty acid amide hydrolase (FAAH) is capable of hydrolyzing and inactivating anandamide and other fatty acid amides that act as agonists for the central cannabinoid (CB1) receptor.1 CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC50 value of 1.3 µM.2 CAY10570 has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed by the enzyme.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cravatt, B.F., Giang, D.K., Mayfield, S.P., et alMolecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384(6604), 83-87 (1996).

    2. Muccioli, G.G., Fazio, N., Scriba, G.K.E., et alSubstituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. J. Med. Chem. 49(1), 417-425 (2006).