An Akt1 translocation inhibitor
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CAY10567

Item No. 10010233

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-diphenyl-6-quinoxalinecarboxylic acid
CAS Number
32387-96-5
Synonyms
  • BML-257
Molecular Formula
C21H14N2O2
Formula Weight
326.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:5): 0.15 mg/mlDMSO: 10 mg/mlEthanol: 0.25 mg/ml
λmax
249, 351 nm
SMILES
OC(=O)c1ccc2nc(c3ccccc3)c(nc2c1)c1ccccc1
InChi Code
InChI=1S/C21H14N2O2/c24-21(25)16-11-12-17-18(13-16)23-20(15-9-5-2-6-10-15)19(22-17)14-7-3-1-4-8-14/h1-13H,(H,24,25)
InChi Key
LFWGZXMTCUOPFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $31

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    250 mg

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    500 mg

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    Product Description

    CAY10567 is an Akt1 translocation inhibitor. At a concentration of 12.5 µM, it prevents the translocation of Akt1 by apparently compromising the function of the PH domain. A structurally similar compound inhibits kinase activity in vitro with an EC50 value of 12 µM by binding to the kinase domain.1 CAY10567 also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) with an IC50 value of 79 µM. 2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lundholt, B.K., Linde, V., Loechel, F., et al. Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN cell 3000 analyzer. J. Biomol. Screen. 10(1), 20-29 (2005).

    2. Rong, F., Chow, S., Yan, S., et al. Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors. Bioorg. Med. Chem. Lett. 17, 1663-1666 (2007).