An EGFR tyrosine kinase inhibitor
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Erbstatin analog

Item No. 10010238

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2,5-dihydroxyphenyl)-2-propenoic acid, methyl ester
CAS Number
63177-57-1
Synonyms
  • Methyl 2,5-dihydoxycinnamate
Molecular Formula
C10H10O4
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
λmax
250, 280, 362 nm
SMILES
COC(=O)\C=C/c1cc(O)ccc1O
InChi Code
InChI=1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
InChi Key
BQCNSTFWSKOWMA-GORDUTHDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $16

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    5 mg

    $59

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    10 mg

    $98

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    50 mg

    $423

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    Product Description

    Erbstatin analog is a stable, potent inhibitor of EGFR kinase activity. It is four-times more stable than erbstatin in calf serum1 and inhibits EGFR tyrosine kinase in vitro similar to erbstatin with an IC50 value of 0.14 µg/ml.1 Erbstatin analog inhibits EGF-stimulated growth in EGFR-overexpressing NIH3T3 cells with an IC50 value of 0.5 µg/ml and efficiently delays the onset of EGF-induced DNA synthesis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Umezawa, K., Hori, T., Tajima, H., et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 260(2), 198-200 (1990).

    2. Umezawa, K., Sugata, D., Yamashita, K., et al. Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells. FEBS Lett. 314(3), 289-292 (1992).