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AG-494

Item № 10010242
CAS № 133550-35-3
Purity ≥98%
product image
                (CAS 133550-35-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $27.00 0.00
     10 mg $51.00 0.00
     25 mg $122.00 0.00
     50 mg $216.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description
Synonyms
  • Tyrphostin AG-494

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation.1 AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 µM in HT-22 cells.2

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Technical Information
Formal Name
2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
CAS Number
133550-35-3
Synonyms
  • Tyrphostin AG-494
Molecular Formula
C16H12N2O3
Formula Weight
280.3
Purity
≥98%
Formulation
A crystalline solid
λmax
370 nm
SMILES
OC1=C(O)C=C(/C=C(C#N)/C(NC2=CC=CC=C2)=O)C=C1
InChI Code
InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
InChI Key
HKHOVJYOELRGMV-XYOKQWHBSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors Journal of Medicinal Chemistry 32(10), 2344-2352 (1989).

2. Sagara, Y., Ishige, K., Tsai, C., et al. Tyrphostins protect neuronal cells from oxidative stress The Journal of Biological Chemisty 277(39), 36204-36215 (2002).

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