An inhibitor of EGF receptor kinase
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AG-17

Item No. 10010248

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-propanedinitrile
CAS Number
10537-47-0
Synonyms
  • GCP 5126
  • Malonoben
  • NSC 242557
  • RG-50872
  • SF 6847
  • Tyrphostin 9
  • Tyrphostin AG-17
Molecular Formula
C18H22N2O
Formula Weight
282.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO: PBS (pH 7.2)(1:6): 0.15 mg/mlEthanol: 12 mg/ml
λmax
249, 365, 466 nm
SMILES
CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C#N)\C#N)=C1
InChi Code
InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
InChi Key
MZOPWQKISXCCTP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    AG-17 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32(10), 2344-2352 (1989).