An inhibitor of protein tyrosine kinase
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AG-490

Item No. 10010311

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
CAS Number
133550-30-8
Synonyms
  • Tyrphostin AG-490
Molecular Formula
C17H14N2O3
Formula Weight
294.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 10 mg/ml
λmax
257, 363 nm
SMILES
N#C/C(=C\c1ccc(O)c(O)c1)/C(=O)NCc1ccccc1
InChi Code
InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChi Key
TUCIOBMMDDOEMM-RIYZIHGNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $61

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    25 mg

    $134

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    50 mg

    $250

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    Product Description

    Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of JAK2 activity and selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no deleterious effect on normal hematopoiesis. AG-490 almost completely blocks growth of all pre-B acute leukemia (ALL) cells at a concentration of 5 µM.1 Furthermore, inhibition of JAK/STAT signaling in satellite cells via AG-490 and the STAT3 inhibitor 5,15-DPP (Item No. 16090) has been used to stimulate muscle regeneration in a model of aging skeletal muscle deterioration.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meydan, N., Grunberger, T., Dadi, H., et al. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379(6566), 645-648 (1996).

    2. Price, F.D., von Maltzahn, J., Bentzinger, C.F., et al. Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nat. Med. 20(10), 1174-1181 (2014).