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Harmine

Item № 10010324
CAS № 442-51-3
Purity ≥98%
product image
                (CAS 442-51-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     250 mg $25.00 0.00
     500 mg $45.00 0.00
     1 g $75.00 0.00

Pricing updated 2019-06-19. Prices are subject to change without notice.

Description

Peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs.1 Harmine is a β-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARγ expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.2 Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNFα, IL-1β, iNOS) and macrophage accumulation in adipose tissue.2

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Technical Information
Formal Name
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
CAS Number
442-51-3
Molecular Formula
C13H12N2O
Formula Weight
212.3
Purity
≥98%
Formulation
A crystalline solid
λmax
242, 302 nm
SMILES
COc1ccc2c(c1)[nH]c1c(C)nccc21
InChI Code
InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChI Key
BXNJHAXVSOCGBA-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Hauner, H. The mode of action of thiazolidinediones Diabetes/Metabolism Research and Reviews 18, S10-S15 (2002).

2. Waki, H., Park, K.W., Mitro, N., et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression Cell Metabolism 5, 357-370 (2007).

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