A unique regulator of PPARγ expression
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Analytical Standard(s)
35146Harmine
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Harmine

Item No. 10010324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
CAS Number
442-51-3
Molecular Formula
C13H12N2O
Formula Weight
212.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.5 mg/mlDMSO: 2 mg/mlEthanol: 1.5 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
242, 302 nm
SMILES
COc1ccc2c(c1)[nH]c1c(C)nccc21
InChi Code
InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChi Key
BXNJHAXVSOCGBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $36

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    500 mg

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    1 g

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    Cayman Chemical
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    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs.1 Harmine is a β-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARγ expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.2 Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNF-α, IL-1β, iNOS) and macrophage accumulation in adipose tissue.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hauner, H. The mode of action of thiazolidinediones. Diabetes Metab. Res. Rev. 18(Suppl. 2), S10-S15 (2002).

    2. Waki, H., Park, K.W., Mitro, N., et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metab. 5(5), 357-370 (2007).