A potent tyrosine kinase inhibitor
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Lavendustin C

Item No. 10010329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid
CAS Number
125697-93-0
Synonyms
  • HDBA
  • NSC 666251
Molecular Formula
C14H13NO5
Formula Weight
275.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
SMILES
Oc1ccc(O)c(CNc2ccc(O)c(c2)C(=O)O)c1
InChi Code
InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
InChi Key
LULATDWLDJOKCX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $123

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    10 mg

    $215

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    50 mg

    $934

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    Product Description

    Lavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM.1 Lavendustin C also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 µM, respectively.2 At a concentration of 10-150 µM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Onoda, T., Iinuma, H., Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J. Nat. Prod. 52(6), 1252-1257 (1989).

    2. O'Dell, T.J., Kandel, E.R., and Grant, S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353(6344), 558-560 (1991).

    3. Burt, H.M., Jackson, J.K., and Salari, H. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. J. Leukoc. Biol. 55(1), 112-119 (1994).