A potent HMG-CoA reductase inhibitor
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Pro-drug Form(s)
10010338Lovastatin
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Lovastatin Hydroxy Acid (sodium salt)

Item No. 10010339

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid, monosodium salt
CAS Number
75225-50-2
Molecular Formula
C24H37O6 • Na
Formula Weight
444.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
231, 238, 246 nm
SMILES
C[C@H]1C=CC2=C[C@H](C)C[C@H](OC([C@@H](C)CC)=O)[C@]2([H])[C@H]1CC[C@@H](O)C[C@@H](O)CC([O-])=O.[Na+]
InChi Code
InChI=1S/C24H38O6.Na/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28;/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-4H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,18+,19+,20-,21-,23-;/m0./s1
InChi Key
LXZBFUBRYYVRQJ-AXHZAXLDSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

    $147

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    25 mg

    $336

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Lovastatin hydroxy acid is a potent and competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM).1 It is the more potent, open ring, hydroxy acid form of its prodrug, lovastatin (Item No. 10010338).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alberts, A.W., Chen, J., Kuron, G., et al. Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA 77(7), 3957-3961 (1980).

    2. Duggan, D.E., Chen, I.W., Bayne, W.F., et al. The physiological disposition of lovastatin. Drug Metab. Dispos. 17(2), 166-173 (1989).