A dual agonist of the CB1 and CB2 receptors
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CB-13

Item No. 10010398

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone
CAS Number
432047-72-8
Synonyms
  • CRA-13
Molecular Formula
C26H24O2
Formula Weight
368.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 5 mg/mlEthanol: 0.2 mg/mlMethanol: 1 mg/ml
λmax
220, 333 nm
SMILES
CCCCCOc1ccc(c2ccccc12)C(=O)c1cccc2ccccc12
InChi Code
InChI=1S/C26H24O2/c1-2-3-8-18-28-25-17-16-24(21-13-6-7-14-22(21)25)26(27)23-15-9-11-19-10-4-5-12-20(19)23/h4-7,9-17H,2-3,8,18H2,1H3
InChi Key
RSUMDJRTAFBISX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Product Description

    CB-13 is a dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors.1 In rats, oral CB-13 (3 mg/kg) potently blocks CB1-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability.1 CB-13 does not possess genotoxic potential, as indicated by negative results in both chromosome aberration and reverse mutation assays.1 The effects of CB-13 on other aspects of CB signaling have not been assessed.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dziadulewicz, E.K., Bevan, S.J., Brain, C.T., et al. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J. Med. Chem. 50(16), 3851-3856 (2007).