A selective inhibitor of PDGF receptor kinase.
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AG-370

Item No. 10010568

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile
CAS Number
134036-53-6
Synonyms
  • NSC 651712
Molecular Formula
C15H9N5
Formula Weight
259.3
Purity
≥95% (cis/trans mixture)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml
λmax
260, 367 nm
SMILES
c12c(ccc(c1)/C=C(\C(=C(\C#N)C#N)N)C#N)[nH]cc2
InChi Code
InChI=1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,20H,19H2/b12-6+
InChi Key
CMMDWEJTQUTCKG-WUXMJOGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $274

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    10 mg

    $481

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    25 mg

    $1,053

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    Product Description

    AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 µM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 µM).1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bryckaert, M.C., Eldor, A., Fontenay, M., et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp. Cell Res. 199, 255-261 (1992).

    2. Levitzki, A., and Gilon, C. Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol. Sci. 12, 171-174 (1991).

    3. Gazit, A., App, H., McMahon, G., et al. Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins. J. Med. Chem. 39, 2170-2177 (1996).

    Product Citations

    Roach, E.E., Chakrabarti, R., Park, N.I., et al. Intrinsic regulation of hemangioma involution by platelet-derived growth factor. Cell Death Dis. 3, e328 (2012).