An internal standard for the quantification of metronidazole
Related Products
Unlabeled Version(s)
9002409Metronidazole
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Metronidazole-d4

Item No. 10010659

Technical Information
Formal Name
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1,1,2,2-d4-1-ol
CAS Number
1261392-47-5
Molecular Formula
C6H5D4N3O3
Formula Weight
Purity
≥99% deuterated forms (d1-d4)
A solid
DMF: 15 mg/mlDMF: 15mg/mLDMSO: 15 mg/mlDMSO: 15mg/mLEthanol: 5 mg/mlEthanol: 5mg/mL
SMILES
CC1=NC=C([N+]([O-])=O)N1C([2H])([2H])C([2H])([2H])O
InChi Code
InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3/i2D2,3D2
InChi Key
VAOCPAMSLUNLGC-RRVWJQJTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Metronidazole-d4 is intended for use as an internal standard for the quantification of metronidazole (Item No. 9002409) by GC- or LC-MS. Metronidazole is an antibiotic that has activity against anaerobic bacteria and protozoa including T. vaginalis, E. histolytica, G. lamblia, C. difficile, and H. pylori.1 It reduces the growth of E. coli in vitro (MIC = 128 mg/L under anaerobic conditions).2 In vivo, metronidazole reduces viable counts of B. fragilis in a rabbit model of infection. Formulations containing metronidazole have been used in the treatment of various infections including H. pylori and C. difficile.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Samuelson, J. Why metronidazole is active against both bacteria and parasites. Antimicrob. Agents Chemother. 43(7), 1533-1541 (1999).

    2. Rylander, M., Holm, S.E., Brorson, J.-E., et alActivity of metronidazole on Bacteroides fragilis and/or Escherichia coli in vitro and in vivo. J. Antimicrob. Chemother. 7(3), 257-267 (1981).