A potent inhibitor of phosphatidic acid generation
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(±)-Lisofylline

Item No. 10010785

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6-dione
CAS Number
6493-06-7
Synonyms
  • BL 194
  • CT-1501R
  • LSF
Molecular Formula
C13H20N4O3
Formula Weight
280.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
274 nm
SMILES
CC(O)CCCCn1c(=O)c2n(C)cnc2n(C)c1=O
InChi Code
InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
InChi Key
NSMXQKNUPPXBRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $81

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    50 mg

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    100 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    (±)-Lisofylline (LSF) is a potent anti-inflammatory agent in which only the (−) optical isomer is biologically active.1,2 LSF inhibits the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.3 LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits IL-12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.1,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, Z., Chen, M., Ellett, J.D., et al. Inflammatory blockade improves human pancreatic islet function and viability. Am. J. Transplant. 5(3), 475-483 (2005).

    2. Wyska, E., Pekala, E., and Szymura-Oleksiak, J. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality 18(8), 644-651 (2006).

    3. Rice, G.C., Brown, P.A., Nelson, R.J., et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc. Natl. Acad. Sci. USA 91(9), 3857-3861 (1994).

    4. Yang, Z.D., Chen, M., Wu, R., et al. The anti-inflammatory compound lisofylline prevents type I diabetes in non-obese diabetic mice. Diabetologia 45(9), 1307-1314 (2002).