A selective, potent FAAH inhibitor
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PF-622

Item No. 10010907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phenyl-4-(2-quinolinylmethyl)-1-piperazinecarboxamide
CAS Number
898235-65-9
Molecular Formula
C21H22N4O
Formula Weight
346.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:5): 0.15 mg/mlDMSO: 2 mg/mlEthanol: 0.3 mg/ml
λmax
232 nm
SMILES
O=C(Nc1ccccc1)N1CCN(CC1)Cc1ccc2ccccc2n1
InChi Code
InChI=1S/C21H22N4O/c26-21(23-18-7-2-1-3-8-18)25-14-12-24(13-15-25)16-19-11-10-17-6-4-5-9-20(17)22-19/h1-11H,12-16H2,(H,23,26)
InChi Key
SNTCRRMCALVGNL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $118

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    10 mg

    $205

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    50 mg

    $888

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    Product Description

    Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-622 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.99 and 0.033 µM when preincubated with human recombinant FAAH for 5 and 60 minutes, respectively.1 Activity-based profiling of various human and murine tissue proteome samples revealed that PF-622 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahn, K., Johnson, D.S., Fitzgerald, L.R., et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46, 13019-13030 (2007).