Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
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KT 5823

Item No. 10010965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
CAS Number
126643-37-6
Molecular Formula
C29H25N3O5
Formula Weight
495.5
Purity
≥95%
Formulation (Request formulation change)
A clear film
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthyl Acetate: 1 mg/ml
λmax
292 nm
SMILES
C[C@]1([C@@]2(OC)C(OC)=O)N(C3=CC=CC=C43)C5=C4C(CN6C)=C(C6=O)C(C7=CC=CC=C87)=C5N8[C@@H](C2)O1
InChi Code
InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
InChi Key
QTYMDECKVKSGSM-YMUMJAELSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 µg

    $41

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    50 µg

    $75

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    100 µg

    $119

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    500 µg

    $467

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    Product Description

    KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM).1 KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.2 KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu. Rev. Pharmacol. Toxicol. 32, 377-397 (1992).

    2. Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. The Journal of Biological Chemisty 275(43), 33536-33541 (2000).