Antagonist of spingosine 1-phosphate type 1 receptor
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W123

Item No. 10010992

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-(3-hexylphenylamino)-2-oxoethylamino)propanoic acid
CAS Number
1345982-24-2
Molecular Formula
C17H26N2O3
Formula Weight
306.4
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.3 mg/ml
λmax
244 nm
SMILES
OC(CCNCC(NC1=CC(CCCCCC)=CC=C1)=O)=O
InChi Code
InChI=1S/C17H26N2O3/c1-2-3-4-5-7-14-8-6-9-15(12-14)19-16(20)13-18-11-10-17(21)22/h6,8-9,12,18H,2-5,7,10-11,13H2,1H3,(H,19,20)(H,21,22)
InChi Key
JXZQHAWCGSVWRW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $392

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    10 mg

    $692

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    Product Description

    Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPγS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization.1 It has a Ki value of 0.69 μM when assessed by SEW2871-induced activation of S1P1.1 Its specificity for other S1P receptor subtypes remains to be determined.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wei, S.H., Rosen, H., Matheu, M.P., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6(12), 1228-1235 (2005).