A thyroid hormone mimetic
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KB2115

Item No. 10011054

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)phenoxy]phenyl]amino-3-oxo-propanoic acid
CAS Number
355129-15-6
Synonyms
  • Eprotirome
Molecular Formula
C18H17Br2NO5
Formula Weight
487.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
202, 217, 249 nm
SMILES
OC(=O)CC(=O)Nc1cc(Br)c(Oc2ccc(O)c(c2)C(C)C)c(Br)c1
InChi Code
InChI=1S/C18H17Br2NO5/c1-9(2)12-7-11(3-4-15(12)22)26-18-13(19)5-10(6-14(18)20)21-16(23)8-17(24)25/h3-7,9,22H,8H2,1-2H3,(H,21,23)(H,24,25)
InChi Key
VPCSYAVXDAUHLT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    25 mg

    $209

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    50 mg

    $315

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    100 mg

    $523

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), promote the reduction of plasma cholesterol levels and induce weight loss. However when administered in high doses, thyroid hormones produce undesirable side effects in the heart, bone and muscle. KB2115 is a synthetic thyroid hormone mimetic. At a dose of 50-200 µg administered to humans once-daily for 14 days, KB2115 lowers total and low-density lipoprotein cholesterol up to 40% without affecting high-density lipoprotein cholesterol levels and without deleterious side effects to the cardiovascular system.1 Unlike the statin class of drugs which decrease cholesterol synthesis, KB2115 stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berkenstam, A., Kristensen, J., Mellström, K., et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc. Natl. Acad. Sci. USA 105(2), 663-667 (2008).