A precusor of sialic acid
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Isomer(s)
31728GalNAc
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cytoskeleton & Motor Proteins

N-acetyl-D-Mannosamine

Item No. 10011060

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(acetylamino)-2-deoxy-β-D-mannopyranose
CAS Number
7772-94-3
Synonyms
  • ManNAc
Molecular Formula
C8H15NO6
Formula Weight
221.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1N(C(C)=O)[H]
InChi Code
InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5+,6-,7-,8-/m1/s1
InChi Key
OVRNDRQMDRJTHS-OZRXBMAMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $13

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    250 mg

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    500 mg

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    1 g

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    Product Description

    Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition as well as the formation and progression of tumors.1 Disruption of sialic acid biosynthesis can result in severe glomerular proteinuria or neuromuscular disorders such as hereditary inclusion body myopathy (HIBM).2 N-Acetyl-D-mannosamine (ManNAc) is the precursor of all physiological sialic acids. Intraperitoneal injection of ManNAc twice daily at 1,000 mg/kg in C57BL/6 mice for 13 days leads to increased sialylation in kidney, liver, blood cells, brain, spinal cord, muscle, heart, lung, and spleen.3 ManNAc reverses hyposialylation and improves glomerular integrity in GneM712T/M712T mice whose key enzyme for sialic acid production has been deleted and may prove therapeutic in the treatment of HIBM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schwarzkopf, M., Knobeloch, K.P., Rohde, E., et al. Sialylation is essential for early development in mice. Proc. Natl. Acad. Sci. USA 99(8), 5267-5270 (2002).

    2. Galeano, B., Klootwijk, R., Manoli, I., et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J. Clin. Invest. 117(6), 1585-1594 (2007).

    3. Gagiannis, D., Gossrau, R., Reutter, W., et al. Engineering the sialic acid in organs of mice using N-propanoylmannosamine. Biochim. Biophys. Acta 1770, 297-306 (2007).