An amino sugar derivative of galactose
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Product Type

Biochemicals
Carbohydrates

Research Area

Cell Biology

GalNAc

Item No. 31728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(acetylamino)-2-deoxy-D-galactose
CAS Number
1811-31-0
Synonyms
  • N-Acetylgalactosamine
  • N-acetyl-D-Galactosamine
Molecular Formula
C8H15NO6
Formula Weight
221.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChi Code
InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8-/m0/s1
InChi Key
MBLBDJOUHNCFQT-OSMVPFSASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 mg

    $69

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    1 g

    $102

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    5 g

    $363

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    Product Description

    GalNAc is an amino sugar derivative of galactose and a component of O-GalNAc glycans.1,2 It is transferred from UDP-GalNAc to the hydroxy group of protein serine or threonine residues by polypeptide GalNAc transferase, forming the Tn antigen, during the first step of mucin-type O-glycosylation.3,2 GalNAc has been used as a targeting moiety for liver-targeted delivery of oligonucleotides.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Y. Preclinical and clinical advances of GalNAc-decorated nucleic acid therapeutics. Mol. Ther. Nucleic Acids 6, 116-132 (2017).

    2. Brockhausen, I., Schachter, H., and Stanley, P. O-GalNAc glycans. Essentials of Glycobiology - NCBI Bookshelf (2009).

    3. Bennett, E.P., Mandel, U., Clausen, H., et al. Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family. Glycobiology 22(6), 736-756 (2012).