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WHI-P131

Item № 10011246
CAS № 202475-60-3
Purity ≥98%
product image
                (CAS 202475-60-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $24.00 0.00
     5 mg $108.00 0.00
     10 mg $192.00 0.00
     25 mg $420.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • Janex 1

Janus kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STATs). JAK3 is abundantly expressed in normal lymphoid cells as well as human lymphoblastic and myeloblastic leukemia cells. WHI-P131 selectively inhibits the tyrosine kinase activity of JAK3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases (IC50 ≥350 µM).1 WHI-P131 induces apoptosis in JAK3-expressing human leukemia cell lines NALM-6 and LC1;19, but not in melanoma or squamous carcinoma cell lines.1

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Technical Information
Formal Name
4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol
CAS Number
202475-60-3
Synonyms
  • Janex 1
Molecular Formula
C16H15N3O3
Formula Weight
297.3
Purity
≥98%
Formulation
A crystalline solid
λmax
227, 247, 333 nm
SMILES
COc1cc2c(ncnc2cc1OC)Nc1ccc(O)cc1
InChI Code
InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChI Key
HOZUXBLMYUPGPZ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Sudbeck, E.A., Liu, X.P., Narla, R.K., et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents Clin. Cancer Res. 5(6), 1569-1582 (1999).

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