An IKKβ and Plk1 inhibitor
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CAY10575

Item No. 10011248

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide
CAS Number
916985-21-2
Synonyms
  • IKK2 Inhibitor 3
  • Polo-like Kinase Inhibitor 1
Molecular Formula
C22H21N3O6S2
Formula Weight
487.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1mg/mLDMSO: 10mg/mLDMSO:PBS(7.2pH) 1:4: 0.2mg/mL
λmax
295 nm
SMILES
COc1cc2c(ncn2c2cc(OCc3ccc(cc3)S(=O)(=O)C)c(s2)C(=O)N)cc1OC
InChi Code
InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)
InChi Key
YYZTVTZCYVZGRB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    CAY10575 inhibits IKKβ and polo-like kinase 1 (Plk1; IC50s = 0.075 and 0.125 µM, respectively).1,2 It also inhibits IKKε (IC50 = <15.8 µM).1 It increases neurite total length in hippocampal neurons isolated from rat embryos when used at concentrations ranging from 0.8 to 20 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bamborough, P., Christopher, J.A., Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg. Med. Chem. Lett. 16(24), 6236-6240 (2006).

    2. Xie, H.-Z., Liu, L.-Y., Ren, J.-X., et al. Pharmacophore modeling and hybrid virtual screening for the discovery of novel IκB kinase 2 (IKK2) inhibitors. J. Biomol. Struct. Dyn. 29(1), 165-179 (2011).

    3. Al-Ali, H., Schürer, S.C., Lemmon, V.P., et al. Chemical interrogation of the neuronal kinome using a primary cell-based screening assay. ACS Chem. Biol. 8(5), 1027-1036 (2013).