A GSK3β inhibitor
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TWS119

Item No. 10011251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol
CAS Number
601514-19-6
Molecular Formula
C18H14N4O2
Formula Weight
318.3
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 0.3 mg/ml
λmax
233, 311 nm
SMILES
Oc1cccc(c1)Oc1ncnc2[nH]c(cc12)c1cccc(N)c1
InChi Code
InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChi Key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $157

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    25 mg

    $341

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    Product Description

    Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ding, S., Wu, T.Y.H., Brinker, A., et al. Synthetic small molecules that control stem cell fate. Proc. Natl. Acad. Sci. USA 100(13), 7632-7637 (2003).