A potent and selective CK2 inhibitor
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CAY10578

Item No. 10011264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5,6,7-tetraiodo-1,3-dioxo-2-isoindolineacetic acid
CAS Number
19231-60-8
Molecular Formula
C10H3I4NO4
Formula Weight
708.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) 1:5: 0.15 mg/mlDMSO: 5 mg/ml
λmax
263 nm
SMILES
OC(=O)CN1C(=O)c2c(C1=O)c(I)c(I)c(I)c2I
InChi Code
InChI=1S/C10H3I4NO4/c11-5-3-4(6(12)8(14)7(5)13)10(19)15(9(3)18)1-2(16)17/h1H2,(H,16,17)
InChi Key
FLSXICNYHDJIAW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $20

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    5 mg

    $81

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    10 mg

    $142

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    25 mg

    $306

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    Product Description

    Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 with an IC50 value of 0.3 µM.1 This compound is ATP competitive, displaying a Ki value of 0.2 µM and only minimally inhibits the activities of other protein kinases (e.g., GSK3, Cdk5, and MSK1).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Golub, A.G., Yakovenko, O.Y., Prykhod'ko, A.O., et al. Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochim. Biophys. Acta 1784(1), 143-149 (2008).