An inhibitor of PP1 and PP2A
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Dinophysistoxin-1

Item No. 10011497

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,2S,5R,6R,8S)-8-[(1R,2E)-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-6'-[(1S,3S)-3-[(2S,3R,6R,11R)-3,11-dimethyl-1,7-dioxaspiro[5.5]undec-2-yl]-1-hydroxybutyl]octahydro-8'-hydroxy-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-1-methyl-2-propenyl]-α,5-dihydroxy-α,10-dimethyl-1,7-dioxaspiro[5.5]undec-10-ene-2-propanoic acid
CAS Number
81720-10-7
Synonyms
  • DTX1
  • 3-methyl Okadaic Acid
Molecular Formula
C45H70O13
Formula Weight
819.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O[C@H](CC[C@@H](C[C@@](C)(O)C(O)=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@]([C@@H]7C)(OCCC7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3
InChi Code
InChI=1S/C45H70O13/c1-25-21-35(56-45(23-25)36(47)13-12-32(55-45)24-42(7,51)41(49)50)26(2)10-11-31-15-17-43(54-31)18-16-34-40(57-43)37(48)30(6)39(53-34)33(46)22-28(4)38-27(3)14-19-44(58-38)29(5)9-8-20-52-44/h10-11,23,26-29,31-40,46-48,51H,6,8-9,12-22,24H2,1-5,7H3,(H,49,50)/b11-10+/t26-,27-,28+,29-,31+,32+,33+,34-,35+,36-,37-,38+,39+,40-,42-,43-,44-,45-/m1/s1
InChi Key
CLBIEZBAENPDFY-HNXGFDTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $548

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    Product Description

    Dinophysistoxin-1 is a marine toxin produced by dinoflagellates that is known to accumulate in shellfish and cause diarrheic shellfish poisoning.1 It inhibits serine/threonine protein phosphatases 1 (PP1) and PP2A (IC50 = 0.104 nM) and has been shown to promote cancer cell growth in tumor cell lines and animal models.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández, D.A., Louzao, M.C., Fraga, M., et al. Experimental basis for the high oral toxicity of dinophysistoxin 1: A comparative study of DSP. Toxins (Basel) 6(1), 211-228 (2014).

    2. Ikehara, T., Imamura, S., Yoshina, A., et al. PP2A inhibition assay using recombinant enzyme for rapid detection of okadaic acid and its analogs in shellfish. Toxins (Basel) 2(1), 195-204 (2010).

    3. Fujiki, H., Suganuma, M., Yoshizawa, S., et al. Mechanisms of action of okadaic acid class tumor promoters on mouse skin. Environ. Health Perspect. 93, 211-214 (1991).