A potent vasoconstrictor isoprostane
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ent-8-iso Prostaglandin F2α

Item No. 10011545

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9β,11β,15R-trihydroxy-(12α)-prosta-5Z,13E-dien-1-oic acid
CAS Number
159812-83-6
Synonyms
  • ent-8-epi PGF2α-d9
  • ent-8-iso PGF2α-d9
  • ent-15-F2t-Isoprostane-d9
Molecular Formula
C20H34O5
Formula Weight
354.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
CCCCC[C@@H](O)/C=C/[C@@H]1[C@@H](O)C[C@@H](O)[C@H]1C/C=C\CCCC(=O)O
InChi Code
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,18-,19+/m1/s1
InChi Key
PXGPLTODNUVGFL-VCKDCIDJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 µg

    $132

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    50 µg

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    100 µg

    $473

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    Product Description

    Isoprostanes are produced by the non-enzymatic, free radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but also have been found to have a potent biological activity. ent-8-iso Prostaglandin F2α (ent-8-iso PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al. Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculature. Free Radic. Biol. Med. 36(2), 163-172 (2004).