A water soluble derivative of PGF2α
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Prostaglandin F2α (tromethamine salt)

Item No. 16020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, tris(hydroxymethyl)aminomethane salt
CAS Number
38562-01-5
Synonyms
  • Dinoprost
  • PGF2α
Molecular Formula
C20H33O5 • C4H12NO3
Formula Weight
475.6
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetone: <5 mg/mlAcetonitrile: <5 mg/mlDMSO: >50 mg/mlEthanol: >50 mg/mlMethanol: >100 mg/mlPBS pH 7.2: >25 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC([O-])=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1.[NH3+]C(CO)(CO)CO
InChi Code
InChI=1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1
InChi Key
IYGXEHDCSOYNKY-RZHHZEQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $258

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    25 mg

    $567

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    Product Description

    PGF2α is a widely distributed prostaglandin occurring in many species.1,2,3 It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.2 PGF2α exhibits its receptor mediated physiological activity at 50-100 nM.2 Maximal ovine myometrial contraction can be achieved at 125 nM PGF2α in vitro.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology. Am. J. Obstet. Gynecol. 107(7), 1111-1130 (1970).

    2. Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu. Rev. Biochem. 47, 997-1029 (1978).

    3. Watanabe, K., Iguchi, Y., Iguchi, S., et al. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2α by bovine lung prostaglandin F synthase. Proc. Natl. Acad. Sci. USA 83(6), 1583-1587 (1986).

    4. Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J. Reprod. Fertil. 103(1), 55-61 (1995).