1-Deoxynojirimycin (hydrochloride)

1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities.^1,2,3,4,5,6 It inhibits the activities of α- and β-glucosidase (IC₅₀s = 35 and 71 µM, respectively).² 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells.³ It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM.⁴ 1-DNJ (1-100 µg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells.⁵ It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.⁶

WARNING This product is not for human or veterinary use.

1. Gao, K., Zheng, C., Wang, T., et al. 1-Deoxynojirimycin: Occurrence, extraction, chemistry, oral pharmacokinetics, biological activities and in silico target fishing. Molecules 21(11), 1600 (2016).

2. Ahuja-Casarín, A.I., Merino-Montiel, P., Vega-Baez, J.L., et al. Tuning the activity of iminosugars: Novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors. J. Enzyme Inhib. Med. Chem. 36(1), 138-146 (2021).

3. Codelli, J.A., Baskin, J.M., Agard, N.J., et al. Second-generation difluorinated cyclooctynes for copper-free click chemistry. J. Am. Chem. Soc. 130(34), 11486-11493 (2008).

4. Papandréou, M.-J., Barbouche, R., Guieu, R., et al. The α-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. Mol. Pharmacol. 61(1), 186-193 (2002).

5. Wang, R.-J., Yang, C.-H., and Hu, M.-L. 1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation. J. Agric. Food Chem. 58(16), 8988-8993 (2010).

6. Liu, Q., Li, X., Li, C., et al. 1-Deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice. Molecules 20(12), 21700-21714 (2015).