Histamine H4 receptor antagonist
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JNJ-7777120

Item No. 10011925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone
CAS Number
459168-41-3
Molecular Formula
C14H16ClN3O
Formula Weight
277.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 14 mg/mlEthanol: 2 mg/ml
λmax
219, 295 nm
SMILES
ClC1=CC=C(NC(C(N2CCN(C)CC2)=O)=C3)C3=C1
InChi Code
InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChi Key
HUQJRYMLJBBEDO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $22

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    5 mg

    $94

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    10 mg

    $161

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    50 mg

    $702

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    Cayman Chemical
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    Product Description

    JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors.1 Its Ki values for the histamine H1-3 receptors exceed 1 μM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters.1 JNJ-777120 inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.).1 It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thurmond, R.L., Desai, P.J., Dunford, P.J., et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J. Pharmacol. Exp. Ther. 309(1), 404-413 (2004).

    2. Dunford, P.J., O'Donnell, N., Riley, J.P., et al. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J. Immunol. 176, 7062-7070 (2006).