Inhibitor of xanthine oxidase
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Active Metabolite(s)
18716Oxipurinol
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Allopurinol

Item No. 10012597

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
CAS Number
315-30-0
Molecular Formula
C5H4N4O
Formula Weight
136.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
λmax
251 nm
SMILES
O=c1nc[nH]c2[nH]ncc12
InChi Code
InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
InChi Key
OFCNXPDARWKPPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $36

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    50 g

    $68

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    100 g

    $123

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    Product Description

    Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).1,2 In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fujimoto, Y., Sakuma, S., Tagami, T., et al. N-ethylmaleimide inhibits xanthine oxidase activity with no detectable change in xanthine dehydrogenase activity in rabbit liver. Life Sci. 68, 517-524 (2000).

    2. Pacher, P., Nivorozhkin, A., and Szabó, C. Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol. Pharmacol. Rev. 58(1), 87-114 (2006).

    3. Day, R.O., Graham, G.G., Hicks, M., et al. Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin. Pharmacokinet. 46(8), 623-644 (2007).