An inhibitor of xanthine oxidase and active metabolite of allopurinol
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Parent Compound(s)
10012597Allopurinol
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Oxipurinol

Item No. 18716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
CAS Number
2465-59-0
Synonyms
  • Alloxanthine
  • NSC 76239
Molecular Formula
C5H4N4O2
Formula Weight
152.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 3 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
λmax
254 nm
SMILES
O=C1C2=C(NN=C2)NC(N1)=O
InChi Code
InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
InChi Key
HXNFUBHNUDHIGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $41

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    Cayman Chemical
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    Product Description

    Oxipurinol is an inhibitor of xanthine oxidase and active metabolite of the xanthine oxidase inhibitor allopurinol (Item No. 10012597).1 Oxipurinol is formed by the oxidation of allopurinol and binds to an enzyme-bound molybdenum cofactor that keeps xanthine oxidase in an inactive state. It inhibits de novo purine and pyrimidine biosynthesis in human fibroblast cultures.2 Oxipurinol also inhibits the growth of L. donovani when used at concentrations ranging from 20 to 50 µg/ml.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Becker, M.A., Argubright, K.F., Fox, R.M., et al. Oxipurinol-associated inhibition of pyrimidine synthesis in human lymphoblasts. Mol. Pharmacol. 10(4), 657-668 (1974).

    2. Kaiser, W.J., and Stocker, K. Purine and pyrimidine biosynthesis in Neurospora crassa and human skin fibroblasts. Alteration by ribosides and ribotides of allopurinol and oxipurinol. Adv. Exp. Med. Biol. 41, 629-635 (1974).

    3. Marr, J.J., and Berens, R.L. Antileishmanial effect of allopurinol. II. Relationship of adenine metabolism in Leishmania species to the action of allopurinol. J. Infect. Dis. 136(6), 724-732 (1977).