A selective LPA1 and LPA3 receptor antagonist
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Ki16425

Item No. 10012659

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid
CAS Number
355025-24-0
Molecular Formula
C23H23ClN2O5S
Formula Weight
475.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 10 mg/mlMethyl Acetate: 20 mg/ml
λmax
276 nm
SMILES
OC(=O)CCSCc1ccc(cc1)c1onc(C)c1NC(=O)OC(C)c1ccccc1Cl
InChi Code
InChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)
InChi Key
LLIFMNUXGDHTRO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $108

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    10 mg

    $157

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    100 mg

    $970

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    Cayman Chemical
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    Product Description

    Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells.1 Ki1642, at 10 µM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohta, H., Sato, K., Murata, N., et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol. Pharmacol. 64(4), 994-1005 (2003).

    2. Yamada, T., Sato, K., Komachi, M., et al. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA. The Journal of Biological Chemisty 279(8), 6595-6605 (2004).