An antimalarial compound
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FR900098 (sodium salt)

Item No. 10012681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[3-(acetylhydroxyamino)propyl]-phosphonic acid, monosodium salt
CAS Number
73226-73-0
Molecular Formula
C5H11NO5P • Na
Formula Weight
219.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: InsoDMSO: InsoEthanol: InsoPBS (pH 7.2): 5mg/mL
SMILES
CC(N(O)CCCP([O-])(O)=O)=O.[Na+]
InChi Code
InChI=1S/C5H12NO5P.Na/c1-5(7)6(8)3-2-4-12(9,10)11;/h8H,2-4H2,1H3,(H2,9,10,11);/q;+1/p-1
InChi Key
LCFXFDGYDKNWMD-UHFFFAOYSA-M
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $110

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    10 mg

    $197

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    Cayman Chemical
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    Product Description

    FR900098 is a derivative of fosmidomycin (Item No. 16000) that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively).1 FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner.1 FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jomaa, H., Wiener, J., Sanderbrand, S., et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), 1573-1576 (1999).