An affinity probe for detection of PGA1
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Unmodified Version(s)
10010Prostaglandin A1
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Prostaglandin A1-biotin

Item No. 10013

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-9-oxo-15S-hydroxy-prosta-10,13E-dien-1-oyl-N'-biotinoyl-1,6-diaminopentane
Synonyms
  • PGA1-biotin
Molecular Formula
C35H58N4O5S
Formula Weight
646.9
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C1[C@H](CCCCCCC(NCCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1
InChi Code
InChI=1S/C35H58N4O5S/c1-2-3-7-14-27(40)21-19-26-20-22-30(41)28(26)15-8-4-5-9-17-32(42)36-23-12-6-13-24-37-33(43)18-11-10-16-31-34-29(25-45-31)38-35(44)39-34/h19-22,26-29,31,34,40H,2-18,23-25H2,1H3,(H,36,42)(H,37,43)(H2,38,39,44)/b21-19+/t26-,27-,28+,29-,31-,34-/m0/s1
InChi Key
VMFBZOVDPMVFHJ-YKKCXQPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $32

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    500 µg

    $120

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    1 mg

    $224

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    5 mg

    $1,038

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    Product Description

    Prostaglandin A1 (PGA1) is one of the cyclopentenone prostaglandins, which have well documented antimitotic and antiproliferative effects.1,2 The activity of the compounds in this class, which includes prostaglandins in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. PGA1-biotin is an affinity probe which allows PGA1 to be detected through an interaction with the biotin ligand. PGA1-biotin was designed to allow PGA1 to be detected in complexes with nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone prostaglandins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bregman, M.D., and Meyskens, F.L., Jr. Inhibition of human malignant melanoma colony-forming cells in vitro by prostaglandin A1. Cancer Res. 43(4), 1642-1645 (1983).

    2. Lacal, P.M., Amici, C., Bonmassar, E., et al. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. J. Pharmacol. Exp. Ther. 271(2), 1096-1102 (1994).

    Product Citations

    Díaz-Dacal, B., Gayarre, J., Gharbi, S., et al. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A1: Implications for antitumoral activity. Cancer Res. 71(12), 4161-4171 (2011).