A PGE1 dehydration product with anti-tumor and vasodilatory activity
Related Products
Active Metabolite(s)
900014215-keto Prostaglandin A1
Functionalized Version(s)
10013Prostaglandin A1-biotin
Isomer(s)
1007015-epi Prostaglandin A1
Pro-drug Form(s)
10020Prostaglandin A1 ethyl ester
Technical Support & Resources

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Prostaglandin A1

Item No. 10010

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15S-hydroxy-9-oxo-prosta-10,13E-dien-1-oic acid
CAS Number
14152-28-4
Synonyms
  • PGA1
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetone: >100 mg/mlDMF: >75 mg/mlDMSO: >50 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >2.4 mg/ml
λmax
216 nm
SMILES
CCCCCC(O)/C=C/[C@H]1C=CC(=O)C1CCCCCCC(=O)O
InChi Code
InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
InChi Key
BGKHCLZFGPIKKU-LDDQNKHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

    $297

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    50 mg

    $1,238

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    Product Description

    Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.1 It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients.2 It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamberg, M., and Samuelsson, B. Prostaglandins in human seminal plasma. The Journal of Biological Chemisty 241(2), 257-263 (1966).

    2. Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al. Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. Clin. Sci. Mol. Med. Suppl. 2, 311s-313s (1975).

    3. Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metastasis Rev. 13(3-4), 309-315 (1994).

    Product Citations

    Schröder, R., Xue, L., Konya, V., et al. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2. PLoS One 7(3), e33329 (2012).