A dual caspase-3/caspase-7 inhibitor
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Ac-DEVD-CHO (trifluoroacetate salt)

Item No. 10017

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide, 2,2,2-trifluoroacetate
Synonyms
  • N-Ac-Asp-Glu-Val-Asp-CHO
Molecular Formula
C20H30N4O11 • XCF3COOH
Formula Weight
502.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C([H])=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C20H30N4O11.C2HF3O2/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26;3-2(4,5)1(6)7/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32);(H,6,7)/t11-,12-,13-,17-;/m0./s1
InChi Key
PAIYHRXEVLCTGC-XVQUUFRESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $50

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    1 mg

    $84

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    5 mg

    $308

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    10 mg

    $569

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    Product Description

    Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).1,2 Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).1 Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK (Item No. 14465), are irreversible.1 Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. The Journal of Biological Chemisty 273(49), 32608-32613 (1998).

    2. Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272(15), 9677-9682 (1997).

    3. Nicholson, D.W., Ali, A., Thornberry, N.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376(6535), 37-43 (1995).

    Product Citations

    Soni, H., and Adebiyi, A. TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways. Sci. Rep. 6, 29041 (2016).