A CysLT1 receptor antagonist
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Alternative(s)
70720MK-571 (sodium salt)
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MK-571

Item No. 10029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid
CAS Number
115104-28-4
Synonyms
  • L-660,711
Molecular Formula
C26H27ClN2O3S2
Formula Weight
515.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
226, 283, 327, 344, 357 nm
SMILES
ClC1=CC=C2C(N=C(/C=C/C3=CC=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=C3)C=C2)=C1
InChi Code
InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
InChi Key
AXUZQJFHDNNPFG-UXBLZVDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $77

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    10 mg

    $132

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    50 mg

    $587

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    Product Description

    MK-571 is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (Ki = 2.1 nM in a radioligand binding assay using isolated human lung membranes).1 It inhibits contractions induced by leukotriene D4 (LTD4; Item No. 20310) or LTE4 (Item No. 20410) in histamine-primed isolated guinea pig trachea (pA2s = 9.4 and 9.1, respectively), but does not inhibit contractions induced by LTC4 (Item No. 20210) in histamine-primed isolated guinea pig trachea when used at a concentration of 190 nM. MK-571 (100 nM) inhibits LTD4-induced calcium mobilization in COS-7 monkey kidney cells expressing the human CysLT1 receptor in a reporter assay.2 MK-571 (5 mg/kg) improves tissue damping and elasticity, markers of lung function, and decreases IL-4 and IL-5 levels in bronchoalveolar lavage fluid (BALF) in a mouse model of ovalbumin-induced asthma.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, T.R., Zamboni, R., Belley, M., et al. Pharmacology of L-660,711 (MK-571): A novel potent and selective leukotriene D4 receptor antagonist. Can. J. Physiol. Pharmacol. 67(1), 17-28 (1989).

    2. Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399(6738), 789-793 (1999).

    3. da Cunha, A.A., Silveira, J.S., Antunes, G.L., et al. Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma. Exp. Lung Res. 47(8), 355-367 (2021).

    Product Citations

    da Cunha, A.A., Silveira, J.S., Antunes, G.L., et al. Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma. Exp. Lung Res. 47(8), 355-367 (2021).

    Nagai, J., Balestrieri, B., Fanning, L.B., et al. P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J. Clin. Invest. 129(12), 5169-5186 (2019).

    Gronert, K., Martinsson-Niskanen, T., Ravasi, S., et al. Selectivity of recombinant human leukotriene D4, leukotriene B4, and lipoxin A4 receptors with aspirin-triggered 15-epi-LXA4 and regulation of vascular and inflammatory responses. Am. J. Pathol. 158(1), 3-9 (2001).