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8-iso Misoprostol

Item No. 10047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-11α,16-dihydroxy-16-methyl-(8β)-prost-13E-en-1-oic acid, methyl ester
Molecular Formula
C22H38O5
Formula Weight
382.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 100 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
CCCCC(C)(O)C/C=C/[C@H]1C(O)CC(=O)[C@H]1CCCCCCC(=O)OC
InChi Code
InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18+,20+,22?/m0/s1
InChi Key
OJLOPKGSLYJEMD-PJCYZMLPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $90

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    5 mg

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    10 mg

    $696

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    Product Description

    Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.1 Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename Cytotec.2 8-iso Misoprostol is one of several impurities which are possible in the production of bulk commercial preparations of misoprostol, and is somewhat difficult to distinguish from other impurities such as 11β-misoprostol.3 The pharmacology and EP receptor binding affinity for 8-iso misoprostol has not been published.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim. Biophys. Acta 1483(2), 285-293 (2000).

    2. Collins, P.W. Misoprostol: Discovery, development, and clinical applications. Med. Res. Rev. 10(2), 149-172 (1990).

    3. Iyer, R.R. Personal Communication. (2002).